In a study by Trappl et al. (2025), researchers explored the relationship between hemophilia and biological aging by examining biomarkers such as telomere length and mitochondrial DNA (mtDNA) copy number. They compared these markers in 99 persons with hemophilia (PwH) and 61 healthy controls. The findings revealed that PwH had significantly shorter telomeres and fewer mtDNA copies than the controls, suggesting accelerated biological aging in PwH. Specifically, telomere length was notably shorter in PwH (6.09 kb) compared to controls (10.07 kb), and mtDNA copy number was also reduced in PwH. The severity of hemophilia was associated with these biomarkers, indicating that more severe cases might experience faster biological aging.
The study utilized quantitative-PCR-based assays to measure these biomarkers and employed linear regression models to assess the association with hemophilia severity. The statistical significance of the differences in telomere length and mtDNA copy number between PwH and controls underscores the potential impact of hemophilia on the aging process. These findings could have implications for the management and treatment of hemophilia, considering the chronic nature of the disease and its effects on patients' quality of life.
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