In a study by Wang et al. (2025), 171 low-income hemophilia patients in Shandong Province were analyzed, revealing that 77.8% had developed hemophiliac arthropathy, a joint condition caused by bleeding. The median age of the patients was 30 years, and their average annual income was notably low at $446.9. Only a small fraction of children received low-dose prophylaxis, a preventive treatment, while the majority of patients relied on inadequate on-demand treatment, which is used to stop bleeding once it starts. The study found a high median annual bleeding rate of 20 events, and a significant 11.7% of patients had contracted viruses from transfusions.
The research highlighted the importance of early prophylaxis in children to protect joint health, as evidenced by the lower Hemophilia Joint Health Scores in children compared to adults. The average annual per capita dosage of clotting factors was 6,182 IU/year, which is low and indicates a need for increased investment in hemophilia care for low-income patients. The study by Wang et al. underscores the critical need for better support and care for this vulnerable population to improve their quality of life and health outcomes.
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